[Antazoline/tetryzoline eyedrops in comparison with levocabastine eyedrops in acute allergic conjunctivitis].

Abstract

BACKGROUND:

Allergic conjunctivitis is one of the most frequent allergic diseases of the anterior eye segment.

METHODS:

This multicentre, clinical trial was an investigation to compare the antiallergic efficacy, local tolerance and safety of Antazolin/Tetryzolin eye drops and Levocabastine eye drops. 69 patients were treated over a 2 weeks course of therapy. The subjective and objective ocular symptoms were documented over the treatment period.

RESULTS:

Both eye drops reduced subjective and objective ocular symptoms effective. The difference between the treatments (p = 0.0395) was the faster onset of action of Antazolin/Tetryzolin 30 minutes after administration of the first drop of trial medication.

CONCLUSION:

A fast and effective onset of action is of high clinical relevance. Therefore the benefits of using Antazolin/Tetryzolin eye drops was clearly outweigh.

• Authors: R Wertheimer, G Blessmann
• Journal: Klinische Monatsblatter fur Augenheilkunde (Klin Monbl Augenheilkd) Vol. 210 Issue 2 Pg. 93-6 (Feb 1997) ISSN: 0023-2165 [Print] Germany
• Vernacular Title: Antazolin/Tetryzolinhaltige Augentropfen im Vergleich zu Levocabastinhaltigen Augentropfen bei akuter allergischer Konjunktivitis.
• PMID: 9229602 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Anti-Allergic Agents
• Drug Combinations
• Histamine H1 Antagonists
• Imidazoles
• Nasal Decongestants
• Ophthalmic Solutions
• Piperidines
• Antazoline
• levocabastine
• tetrahydrozoline

Topics

• Acute Disease
• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Antazoline (administration & dosage, adverse effects)
• Anti-Allergic Agents (administration & dosage, adverse effects)
• Conjunctivitis, Allergic (drug therapy)
• Dose-Response Relationship, Drug
• Double-Blind Method
• Drug Administration Schedule
• Drug Combinations
• Female
• Histamine H1 Antagonists (administration & dosage, adverse effects)
• Humans
• Imidazoles (administration & dosage, adverse effects)
• Male
• Middle Aged
• Nasal Decongestants (administration & dosage, adverse effects)
• Ophthalmic Solutions
• Piperidines (administration & dosage, adverse effects)