Long-term follow-up on the treatment of endometriosis with the GnRH-agonist buserelinacetate. Long-term follow-up data (up to 98 months) of 42 patients with endometriosis who were treated with GnRH-agonist buserelinacetate (Suprecur), were evaluated in respect of recurrence of pain symptoms and pregnancy outcome.

Abstract

OBJECTIVE:

In our previous study, 119 patients with histologically confirmed endometriosis underwent a 'three-step' therapy between 1987 and 1989, where surgical removal of endometriosis was followed by a 6 month treatment with 3 x 300 microgram buserelinacetate daily intranasally and a second look laparoscopy or laparotomy with removal of residuals. Long-term follow-up data in respect of recurrence of symptoms and pregnancy outcome were investigated.

STUDY-DESIGN:

Long-term follow-up data of 42 out of 119 treated patients on the post-treatment effect were obtained using a special questionnaire. Recurrence of dysmenorrhea, dyspareunia and pelvic pain was defined as recurrence of disease. The follow-up period was up to 98 months with a median time of 82.5 months.

RESULTS:

Out of the 42 patients, 23 complained of infertility. Fourteen out of these 23 patients became pregnant during the follow-up period, resulting in 23 pregnancies with 18 newborns, 4 miscarriages and one ectopic pregnancy. Ten patients conceived spontaneously, stimulation program became necessary in the rest of patients. Twenty-eight of the 42 patients complained recurrence of symptoms with median first onset at 10.7 months. Improvement on quality of life and subjective conditions were reported by 30 patients.

CONCLUSIONS:

Our study suggests that the 'three-step' therapy of endometriosis with GnRH-agonist buserelinacetate leads to a significant improvement on the quality of life and well being in the majority of the patients and to a high pregnancy rate. This treatment represents a favourable approach in the management of endometriosis.

• Authors: P A Regidor, M Regidor, K Kato, U W Bier, K Bühler, A E Schindler
• Journal: European journal of obstetrics, gynecology, and reproductive biology (Eur J Obstet Gynecol Reprod Biol) Vol. 73 Issue 2 Pg. 153-60 (Jun 1997) ISSN: 0301-2115 [Print] Ireland
• PMID: 9228497 (Publication Type: Journal Article)

Chemical References

• Receptors, LHRH
• Buserelin

Topics

• Adult
• Buserelin (therapeutic use)
• Endometriosis (drug therapy, epidemiology)
• Evaluation Studies as Topic
• Female
• Follow-Up Studies
• Humans
• Incidence
• Infertility, Female (drug therapy)
• Pelvic Pain (drug therapy, etiology)
• Pregnancy
• Pregnancy Outcome
• Receptors, LHRH (agonists)
• Recurrence
• Surveys and Questionnaires
• Time Factors
• Treatment Outcome