Abstract | OBJECTIVE: METHODS: Ten patients with RA involving the wrist were evaluated before treatment with methotrexate and hydroxychloroquine, and then mean 14 mo later with a followup evaluation. Clinical variables, laboratory measurements, and MRI using various techniques (T1 weighted image, T2 weighted image, fat suppression T2 weighted image, postcontrast T1 weighted image, postcontrast dynamic image, postcontrast 3 dimensional image) were observed. Remission was defined by ACR criteria. MRI changes were observed using 3 variables: extent of synovial proliferation; extent of bone marrow edema; and development of new erosion. In 6 of 10 patients, synovial signal intensity time curve changes at 30 s (E30 ratio) were determined for quantitative assessment of synovitis. RESULTS: Four patients achieved remission and 6 did not. All patients in remission showed decrease in extent of synovial proliferation and bone marrow edema with no newly developed erosion after treatment, compared to baseline. Five of 6 patients in nonremission showed newly developed erosions with variable changes in extent of synovial proliferation and bone marrow edema. E30 ratio was determined in 3 patients in the remission group and 3 in the nonremission group, with 48% reduction in the former compared to 9% reduction in the latter. CONCLUSION: MRI is feasible for objectively defining remission and assessing the therapeutic effect of antirheumatic drugs; utility of MRI measures in clinical remission criteria remains to be verified.
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Authors | J Lee, S K Lee, J S Suh, M Yoon, J H Song, C H Lee |
Journal | The Journal of rheumatology
(J Rheumatol)
Vol. 24
Issue 7
Pg. 1303-8
(Jul 1997)
ISSN: 0315-162X [Print] Canada |
PMID | 9228129
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antirheumatic Agents
- Contrast Media
- Organometallic Compounds
- Hydroxychloroquine
- Pentetic Acid
- Gadolinium DTPA
- Methotrexate
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Topics |
- Adult
- Antirheumatic Agents
(administration & dosage)
- Arthritis, Rheumatoid
(diagnosis, drug therapy, pathology)
- Contrast Media
- Evaluation Studies as Topic
- Female
- Gadolinium DTPA
- Humans
- Hydroxychloroquine
(administration & dosage)
- Magnetic Resonance Imaging
- Male
- Methotrexate
(administration & dosage)
- Middle Aged
- Organometallic Compounds
- Pentetic Acid
(analogs & derivatives)
- Remission Induction
- Remission, Spontaneous
- Wrist
(pathology)
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