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Does pharmacokinetic variability influence the efficacy of high-dose methotrexate for the treatment of children with acute lymphoblastic leukemia: what can we learn from small studies?

AuthorsW E Evans, M V Relling, J M Boyett, C H Pui
JournalLeukemia research (Leuk Res) Vol. 21 Issue 5 Pg. 435-7 (May 1997) ISSN: 0145-2126 [Print] ENGLAND
PMID9225072 (Publication Type: Comment, Journal Article, Review)
Chemical References
  • Antimetabolites, Antineoplastic
  • Methotrexate
Topics
  • Antimetabolites, Antineoplastic (pharmacokinetics, therapeutic use)
  • Child
  • Disease-Free Survival
  • Dose-Response Relationship, Drug
  • Humans
  • Methotrexate (pharmacokinetics, therapeutic use)
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma (blood, drug therapy)
  • Prognosis
  • Recurrence
  • Risk Assessment

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