Abstract |
The mean survival rates of female BDF1 mice transplanted intravenously (i.v.) with murine L1210 leukemia cells were significantly prolonged by intraperitoneal (i.p.) pretreatment (before i.v. transplantation) or by i.p. pre- and post-treatment (before and after the i.v. transplantation) with heat-killed Actinobacillus suis cells ATCC 15557 (AS 15557) alone, as compared with untreated L1210-leukemia-cell-bearing control mice. However, significant prolongation of the mean survival rates was not elicited by the i.p. post-treatment with AS 15557 alone. When 5-fluorouracil (5-FU) was applied i.p. to mice receiving post-treatment with AS 15557 alone, the mean survival rates of the L1210-leukemia-cell-bearing mice were significantly prolonged. The antileukemic action of AS 15557, alone or in combination with 5-FU, against L1210 leukemia was superior to that of a streptococcal preparation (OK-432) and was almost the same as of bacillus Calmette-Guérin with or without 5-FU. The results suggest the possibility that the synergism of AS 15557 in combination with 5-FU may be dependent on the relationship between the indirect immunological function of AS 15557 and the direct cytotoxic action of 5-FU on L1210 leukemia cells.
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Authors | T Watanabe, S Itoh |
Journal | Cancer immunology, immunotherapy : CII
(Cancer Immunol Immunother)
Vol. 44
Issue 4
Pg. 216-20
(Jun 1997)
ISSN: 0340-7004 [Print] Germany |
PMID | 9222280
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antimetabolites, Antineoplastic
- Antineoplastic Agents
- Picibanil
- Fluorouracil
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Topics |
- Actinobacillus
(cytology, physiology)
- Animals
- Antimetabolites, Antineoplastic
(therapeutic use)
- Antineoplastic Agents
(therapeutic use)
- Combined Modality Therapy
- Female
- Fluorouracil
(therapeutic use)
- Immunization
(methods)
- Leukemia L1210
(mortality, pathology, therapy)
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mycobacterium bovis
(cytology, physiology)
- Neoplasm Transplantation
- Picibanil
(therapeutic use)
- Survival Rate
- Tumor Cells, Cultured
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