Lack of resistance to erythromycin, rifampicin and ciprofloxacin in 98 clinical isolates of Legionella pneumophila.

Abstract

Ninety-eight consecutive clinical isolates of Legionella pneumophila were tested for erythromycin, rifampicin and ciprofloxacin susceptibility. MICs, determined by agar dilution testing, were in the range 0.06-1 mg/L of erythromycin, 0.007-0.015 mg/L of rifampicin and 0.015-0.03 mg/L of ciprofloxacin. No resistance against the antibiotics tested was detected. It is thus likely that therapeutic failures in legionnaires' disease are not related to the emergence of resistance against commonly used antimicrobial agents.

• Authors: C Onody, P Matsiota-Bernard, C Nauciel
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 39 Issue 6 Pg. 815-6 (Jun 1997) ISSN: 0305-7453 [Print] England
• PMID: 9222053 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Anti-Infective Agents
• Antibiotics, Antitubercular
• Ciprofloxacin
• Erythromycin
• Rifampin

Topics

• Anti-Bacterial Agents (pharmacology)
• Anti-Infective Agents (pharmacology)
• Antibiotics, Antitubercular (pharmacology)
• Ciprofloxacin (pharmacology)
• Drug Resistance, Microbial (physiology)
• Erythromycin (pharmacology)
• Legionella pneumophila (drug effects, metabolism)
• Microbial Sensitivity Tests
• Rifampin (pharmacology)