Abstract | CONTEXT: OBJECTIVE: DESIGN: Analysis of data from a multicenter, randomized, double-blind, placebo-controlled clinical trial. PARTICIPANTS: A total of 4736 persons aged 60 years and older with systolic blood pressure between 160 and 219 mm Hg and diastolic blood pressure below 90 mm Hg who participated in the Systolic Hypertension in the Elderly Program (SHEP). INTERVENTION: MAIN OUTCOME MEASURES: RESULTS: During an average of 4.5 years of follow-up, fatal or nonfatal heart failure occurred in 55 of 2365 patients randomized to active therapy and 105 of the 2371 patients randomized to placebo (relative risk [RR], 0.51; 95% confidence interval [CI], 0.37-0.71; P<.001; number needed to treat to prevent 1 event [NNT], 48). Among patients with a history of or electrocardiographic evidence of prior myocardial infarction (MI), the RR was 0.19 (95% CI, 0.06-0.53; P=.002; NNT, 15). Older patients, men, and those with higher systolic blood pressure or a history of or electrocardiographic evidence of MI at baseline had higher risk of developing heart failure. CONCLUSION:
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Authors | J B Kostis, B R Davis, J Cutler, R H Grimm Jr, K G Berge, J D Cohen, C R Lacy, H M Perry Jr, M D Blaufox, S Wassertheil-Smoller, H R Black, E Schron, D M Berkson, J D Curb, W M Smith, R McDonald, W B Applegate |
Journal | JAMA
(JAMA)
Vol. 278
Issue 3
Pg. 212-6
(Jul 16 1997)
ISSN: 0098-7484 [Print] United States |
PMID | 9218667
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antihypertensive Agents
- Diuretics
- Atenolol
- Chlorthalidone
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Topics |
- Aged
- Antihypertensive Agents
(therapeutic use)
- Atenolol
(therapeutic use)
- Chlorthalidone
(therapeutic use)
- Diuretics
(therapeutic use)
- Double-Blind Method
- Electrocardiography
- Female
- Heart Failure
(prevention & control)
- Humans
- Hypertension
(drug therapy, physiopathology)
- Male
- Middle Aged
- Myocardial Infarction
- Survival Analysis
- Systole
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