Abstract | BACKGROUND: METHODS: RESULTS:
Methotrexate was rapidly absorbed in all patients. Peak concentrations (Cmax) varied considerably, ranging from 0.25-0.87 micro M. The mean Cmax values were similar in all patient groups (0.59 +/- 0.12, 0.69 +/- 0.16 and 0.54 +/- 0.18 micro M, P not significant) for Crohn's disease, ulcerative colitis and rheumatoid arthritis, respectively. The mean area under curve in 120 min (AUC0-120) was also similar in all patient groups (32.9 + 11.3, 43.6 + 9.9 and 41.8 + 14.9 ng.min/mL, P not significant) for Crohn's disease, ulcerative colitis and rheumatoid arthritis, respectively. The mean time to reach Cmax, (tmax), varied between patient groups (84, 112 and 95 min, respectively, with a significant difference, P < 0.02, between the Crohn's disease and ulcerative colitis groups. A negative correlation was found between methotrexate dosage/kg and Cmax (r = -0.74) only in Crohn's disease patients but not in the other patient groups. CONCLUSIONS:
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Authors | M Moshkowitz, R Oren, M Tishler, F M Konikoff, E Graff, S Brill, M Yaron, T Gilat |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 11
Issue 3
Pg. 569-73
(Jun 1997)
ISSN: 0269-2813 [Print] England |
PMID | 9218084
(Publication Type: Journal Article)
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Chemical References |
- Folic Acid Antagonists
- Methotrexate
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Topics |
- Adult
- Aged
- Female
- Folic Acid Antagonists
(pharmacokinetics)
- Humans
- Inflammatory Bowel Diseases
(metabolism)
- Male
- Methotrexate
(pharmacokinetics)
- Middle Aged
- Time Factors
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