Abstract | BACKGROUND: OBJECTIVE: METHODS: In a double-blind, placebo-controlled study, 151 children with sinusitis were recruited from a general pediatric outpatient clinic and 89 completed a 3-week trial. Treatment consisted of amoxicillin- clavulanate potassium, 40 mg/kg/d tid, combined with bid nasal spray of either budesonide, 50 micrograms, to each nostril (n = 43) or placebo )n = 46_ for 3 weeks. Patients maintained daily symptom cards throughout the study and were examined by the same physician each week. RESULTS: Clinical symptoms and signs decreased significantly in both treatment groups in comparison to baseline (P < .01). We detected a significant improvement in the scores of the cough and nasal discharge at the end of second week in the budesonide group when compared with placebo (P < .05). Friedman nonparametric repeated measures ANOVA test revealed a significant decrease in the total weekly scores of cough during the second week of budesonide treatment (P < .001) in contrast to continuous decline during the second and third weeks in the placebo group (P < .001 and P < .05, respectively). While the nasal discharge score decreased significantly during the second week in the budesonide group (P < .01), no significant effect on the nasal discharge score was observed in the placebo group. CONCLUSION:
|
Authors | I B Barlan, E Erkan, M Bakir, S Berrak, M M Başaran |
Journal | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
(Ann Allergy Asthma Immunol)
Vol. 78
Issue 6
Pg. 598-601
(Jun 1997)
ISSN: 1081-1206 [Print] United States |
PMID | 9207726
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Aerosols
- Anti-Bacterial Agents
- Anti-Inflammatory Agents
- Penicillins
- Pregnenediones
- Budesonide
- Amoxicillin
|
Topics |
- Acute Disease
- Adolescent
- Aerosols
- Amoxicillin
(therapeutic use)
- Anti-Bacterial Agents
(therapeutic use)
- Anti-Inflammatory Agents
(administration & dosage)
- Budesonide
- Child
- Child, Preschool
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Humans
- Infant
- Male
- Penicillins
(therapeutic use)
- Pregnenediones
(administration & dosage)
- Sinusitis
(drug therapy)
|