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Cefodizime once daily in the treatment of lower respiratory tract infections.

Abstract
Cefodizime (CAS 69739-16-8, HR 221) is a new third-generation cephalosporin with pharmacokinetic properties that make it suitable for once-daily administration in the treatment of lower respiratory tract infections (LRTI). Ninety-nine adult hospitalized patients (66 males, 33 females, median age 57.5 years) received a once-daily injection of 2 g cefodizime for LRTI. Median treatment duration was 8 days. Forty-two patients received cefodizime intravenously and 57 intramuscularly. Indications for treatment were as follows; primary lobar pneumonia (n = 36), bronchopneumonia (n = 14), secondary pneumonia (n = 3), aspiration pneumonia (n = 5), acute exacerbation of chronic bronchitis (n = 21), and of bronchiectasis (n = 9) and acute purulent bronchitis (n = 11). General condition was good in 29 patients and poor in 58; 12 patients were critically ill. The following pathogens were isolated at baseline (source: bronchial secretions, sputum or blood): S. pneumoniae (n = 47), Haemophilus spp. (n = 17), M. catarrhalis (n = 6), Streptococcus spp. (n = 9), Staphylococcus spp. (n = 5), Klebsiella spp. (n = 4), Pseudomonas spp. (n = 1), A. calcoaceticus (n = 1) and anaerobic organisms (n = 7). Fifty-nine patients were evaluable for bacteriological response and 82 for clinical response. Bacteriological outcome was satisfactory in 29/30 patients having LRTI with parenchymal involvement (97%) and in 29/29 patients without parenchymal involvement (100%). Clinical cure was achieved in 41/43 evaluable patients with parenchymal involvement (95%) and in 37/39 patients without parenchymal involvement (95%) in the per-protocol analysis and in 54/58 patients (93%) and 37/41 patients (93%), respectively, in the clinical intention-to-treat analysis. Three of the patients with an unsatisfactory clinical response died of infection during the study. Cefodizime was well tolerated. Adverse reactions--all of mild intensity--were tachycardia, lumbalgia and dizziness, each occurring in one patient. Cefodizime 2 g once daily either i.m. or i.v. was effective in the treatment of lower respiratory tract infections in hospitalized patients.
AuthorsC F Piovano, B C Palombini, E E Dagrosa, F Mendoza, E B Facco
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 47 Issue 5 Pg. 674-7 (May 1997) ISSN: 0004-4172 [Print] Germany
PMID9205786 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Multicenter Study)
Chemical References
  • Cephalosporins
  • Cefotaxime
  • cefodizime
Topics
  • Adult
  • Aged
  • Bronchitis (drug therapy)
  • Cefotaxime (administration & dosage, analogs & derivatives, therapeutic use)
  • Cephalosporins (administration & dosage, therapeutic use)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pneumonia, Bacterial (drug therapy)
  • Respiratory Tract Infections (drug therapy)

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