Abstract | BACKGROUND: The aetiology and pathophysiology of ulcerative colitis remains unclear; however, there is increasing recognition of the critical role of inflammatory cytokines in the pathogenesis of this disease. Among these, tumour necrosis factor alpha ( TNF alpha) seems to play an important role. AIM: METHODS: Six cottontop tamarins with confirmed ulcerative colitis received repeated doses of CDP571. Progression of disease was assessed by measuring both body weight and rectal biopsy pathology. RESULTS: All animals showed a rapid improvement in clinical condition and rectal biopsy pathology that was maintained following completion of the therapy. CONCLUSION:
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Authors | P E Watkins, B F Warren, S Stephens, P Ward, R Foulkes |
Journal | Gut
(Gut)
Vol. 40
Issue 5
Pg. 628-33
(May 1997)
ISSN: 0017-5749 [Print] England |
PMID | 9203942
(Publication Type: Journal Article)
|
Chemical References |
- Antibodies, Monoclonal
- Tumor Necrosis Factor-alpha
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Topics |
- Animals
- Antibodies, Monoclonal
(blood, pharmacology, therapeutic use)
- Colitis, Ulcerative
(pathology, therapy, veterinary)
- Female
- Male
- Monkey Diseases
(pathology, therapy)
- Rectum
(pathology)
- Saguinus
- Tumor Necrosis Factor-alpha
(immunology)
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