Bacterial antigen activation of Vdelta1 and Vdelta2 gammadelta T cells of persons infected with human immunodeficiency virus type 1.

Abstract

Vdelta2 gammadelta T cells are readily activated by microbial antigens. In persons infected with human immunodeficiency virus type 1 (HIV-1), the number of gammadelta T cells remains the same or increases in association with reversal of the Vdelta2/Vdelta1 ratio from > or = 1 to < 1. Vdelta2 T cell responses to microbial antigens were tested in 11 HIV-1-infected (> or = 500 CD4 cells/mm3) and 7 uninfected persons. In persons with HIV-1 infection, Mycobacterium tuberculosis expanded Vdelta2 cells in 1 person as did Salmonella typhimurium in 4; however, Candida albicans antigens did not lead to more Vdelta2 cells. Vdelta2 responses to M. tuberculosis were enhanced by interleukin (IL)-2 in HIV-1-infected persons (from 1 subject to 7; P < .01) and were associated with increased interferon-gamma production. Bacterial antigens and IL-2 increased HIV-1 replication; M. tuberculosis antigens induced the greatest increase. Thus, in HIV-1-infected persons with > or = 500 CD4 cells/mm3, Vdelta2 T cell responses to bacterial antigens remain intact.

• Authors: K A Chervenak, M M Lederman, W H Boom
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 175 Issue 2 Pg. 429-33 (Feb 1997) ISSN: 0022-1899 [Print] United States
• PMID: 9203665 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antigens, Bacterial
• Antigens, Fungal
• HIV Core Protein p24
• Interleukin-2
• Receptors, Antigen, T-Cell, gamma-delta
• Interferon-gamma

Topics

• Antigens, Bacterial (immunology)
• Antigens, Fungal (immunology)
• Candida albicans (immunology)
• Flow Cytometry
• HIV Core Protein p24 (biosynthesis)
• HIV Infections (immunology)
• HIV-1 (growth & development)
• Humans
• Interferon-gamma (metabolism)
• Interleukin-2 (immunology)
• Lymphocyte Activation
• Mycobacterium tuberculosis (immunology)
• Receptors, Antigen, T-Cell, gamma-delta (immunology)
• Salmonella typhimurium (immunology)
• T-Lymphocyte Subsets (immunology)
• T-Lymphocytes (immunology)