Abstract |
The effectiveness of intermittent low-dose trimethoprim-sulfamethoxazole ( TMP-SMZ) for the prophylaxis of recurrent urinary infection is well established in adults. The present study assessed the effectiveness and safety of intermittent low-dose TMP-SMZ in 35 children (24 boys, 11 girls, aged 1 month to 9 years, median age 5 months) with vesicoureteral reflux; 18 children had bilateral reflux. A total of 53 refluxing ureters were graded as I in 2, II in 16, III in 19, IV in 14, and V in 2 cases. The children were given 1 mg/kg body weight of trimethoprim together with 5 mg/kg of sulfamethoxazole at bedtime every other day for 6-50 months (mean +/- SD, 22.9 +/- 11.7 months). None of the boys had a recurrence of urinary infection, while 2 of the 11 girls had a total of 7 recurrences during the prophylaxis period, with a recurrence rate of 0.027 per patient month in girls. Both girls were over 3 years and had a mildly unstable bladder. Transient neutropenia (< 1,000/microliter) developed in 2 infants during the prophylaxis period, but disappeared spontaneously. Intermittent low-dose TMP-SMZ seemed very effective for the prevention of recurrent urinary infection in children with ureteral reflux even of higher grades.
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Authors | C Hori, M Hiraoka, H Tsukahara, S Tsuchida, M Sudo |
Journal | Pediatric nephrology (Berlin, Germany)
(Pediatr Nephrol)
Vol. 11
Issue 3
Pg. 328-30
(Jun 1997)
ISSN: 0931-041X [Print] Germany |
PMID | 9203183
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Anti-Infective Agents, Urinary
- Trimethoprim, Sulfamethoxazole Drug Combination
- Creatinine
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Topics |
- Anti-Infective Agents, Urinary
(adverse effects, therapeutic use)
- Child
- Child, Preschool
- Creatinine
(blood, urine)
- Female
- Humans
- Infant
- Infant, Newborn
- Kidney Function Tests
- Male
- Trimethoprim, Sulfamethoxazole Drug Combination
(adverse effects, therapeutic use)
- Urinary Tract Infections
(etiology, prevention & control)
- Vesico-Ureteral Reflux
(complications)
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