HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Hepatoprotective effect of the fractions of Ban-zhi-lian on experimental liver injuries in rats.

Abstract
The hepatoprotective effect of various fractions (n-hexane, CHCl3, EtOAc, n-BuOH, and H2O) of Ban-zhi-lian derived from Scutellaria rivularis Benth was studied against carbon tetrachloride (CCl4), D-galactosamine (D-GalN) and acetaminophen (APAP)-induced acute hepatotoxicity in rats. Liver damage was assessed by quantifying serum activities of glutamate oxaloacetate transaminase (sGOT) and glutamate pyruvate transaminase (sGPT), as well as by histopathological examination. The results indicated that the CHCl3 fraction and EtOAc fractions exhibited the greatest hepatoprotective effects on CCl4-induced liver injuries, the CHCl3 fraction and n-hexane fraction are most potent against D-GalN-induced intoxication, and the CHCl3 fraction represented the most liver-protective effect on APAP-induced hepatotoxicity. The pathological changes of hepatic lesions caused by these three hepatotoxicants were improved by treatment with the fractions mentioned above, which were compared to Glycyrrhizin (GLZ) and Silymarin as standard reference medicines.
AuthorsC C Lin, D E Shieh, M H Yen
JournalJournal of ethnopharmacology (J Ethnopharmacol) Vol. 56 Issue 3 Pg. 193-200 (May 1997) ISSN: 0378-8741 [Print] Ireland
PMID9201608 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Plant Extracts
  • Silymarin
  • Acetaminophen
  • Glycyrrhizic Acid
  • Galactosamine
  • Carbon Tetrachloride
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Glycyrrhetinic Acid
Topics
  • Acetaminophen (toxicity)
  • Alanine Transaminase (blood)
  • Animals
  • Aspartate Aminotransferases (blood)
  • Carbon Tetrachloride (toxicity)
  • Galactosamine (toxicity)
  • Glycyrrhetinic Acid (analogs & derivatives, pharmacology)
  • Glycyrrhizic Acid
  • Liver (drug effects, injuries, pathology)
  • Male
  • Medicine, East Asian Traditional
  • Plant Extracts (chemistry, pharmacology)
  • Rats
  • Rats, Wistar
  • Silymarin (pharmacology)
  • Taiwan

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: