Abstract | BACKGROUND: Epidemiologic evidence and meta-analyses of data from early clinical trials suggest that lowering the levels of cholesterol does not reduce the events of stroke. These analyses have not included more recent clinical trials using reductase inhibitors. OBJECTIVE: To conduct a meta-analysis of the effect of reducing cholesterol levels on stroke in all reported clinical trials of primary (n = 4) and secondary (n = 8) prevention of coronary heart disease that used reductase inhibitor monotherapy and provided information on incident stroke. RESULTS: Analysis of combined data from primary and secondary prevention trials showed a highly statistically significant reduction of stroke associated with the use of reductase inhibitor monotherapy (27% reduction in stroke; P = .001). Analysis of secondary prevention trials alone disclosed a similar statistically significant effect (32% reduction in stroke; P = .001). A smaller nonsignificant reduction in stroke was noted in the primary prevention trials (15% reduction in stroke; P = .48). CONCLUSIONS:
|
Authors | J R Crouse 3rd, R P Byington, H M Hoen, C D Furberg |
Journal | Archives of internal medicine
(Arch Intern Med)
Vol. 157
Issue 12
Pg. 1305-10
(Jun 23 1997)
ISSN: 0003-9926 [Print] United States |
PMID | 9201004
(Publication Type: Journal Article, Meta-Analysis)
|
Chemical References |
- Anticholesteremic Agents
- Lovastatin
- Simvastatin
- Hydroxymethylglutaryl CoA Reductases
- Pravastatin
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Anticholesteremic Agents
(therapeutic use)
- Cerebrovascular Disorders
(prevention & control)
- Coronary Disease
(prevention & control)
- Female
- Humans
- Hydroxymethylglutaryl CoA Reductases
- Incidence
- Lovastatin
(analogs & derivatives, therapeutic use)
- Male
- Middle Aged
- Pravastatin
(therapeutic use)
- Simvastatin
- Treatment Outcome
|