Lactic acidosis traced to thiamine deficiency related to nationwide shortage of multivitamins for total parenteral nutrition -- United States, 1997.

Abstract

Since November 1996, there has been a nationwide shortage of intravenous (IV) multivitamins (MVIs) used in U.S. hospitals and home-health-care agencies for total parenteral nutrition (TPN). Patients receiving TPN without MVI supplementation are at risk for thiamine deficiency and life-threatening complications associated with severe deficiency of thiamine, a coenzyme necessary for oxidation of keto acids (Figure 1). This report describes three patients receiving TPN who had thiamine deficiency-related lactic acidosis in 1997 and presents recommendations for alternatives to parenteral MVI during the shortage.

• Authors: Centers for Disease Control and Prevention (CDC)
• Journal: MMWR. Morbidity and mortality weekly report (MMWR Morb Mortal Wkly Rep) Vol. 46 Issue 23 Pg. 523-8 (Jun 13 1997) ISSN: 0149-2195 [Print] United States
• PMID: 9191033 (Publication Type: Case Reports, Journal Article)

Chemical References

• Vitamins

Topics

• Acidosis, Lactic (etiology)
• Adult
• Child
• Female
• Humans
• Male
• Parenteral Nutrition, Total
• Thiamine Deficiency (complications, prevention & control)
• United States
• Vitamins (supply & distribution)