Abstract |
Rats with bilateral, electrophysiologically guided, ibotenic acid lesions of the gustatory thalamus (THLX) were tested for their ability to perform a variety of taste-guided behaviors. First, in daily 30-min sessions, the rats were given repeated 10-s access periods to a range of concentrations of sucrose, NaCl, or QHCl, plus water. Both the control and the THLX rats exhibited similar concentration-response functions, regardless of hydrational state. Next, on 3 trials, the rats were given 15 min access to 0.3 M l-alanine and then injected with LiCl (0.15 M, 1.33 ml/100 g body weight ip). All rats learned a taste aversion following 1 pairing with LiCl. Finally, on 3 separate occasions, the rats were injected with furosemide, and Na(+)-appetite was evaluated 24 hr later. All rats expressed an equivalent sodium appetite after the first furosemide injection, but only the control rats increased intake of 0.51 M NaCl with repeated sodium depletions. These observations reinforce prior data implying that an intact gustatory thalamus is not necessary for the expression of some taste-guided behaviors.
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Authors | G Scalera, P S Grigson, R Norgren |
Journal | Behavioral neuroscience
(Behav Neurosci)
Vol. 111
Issue 3
Pg. 633-45
(Jun 1997)
ISSN: 0735-7044 [Print] United States |
PMID | 9189278
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Dietary Sucrose
- Sodium, Dietary
- Ibotenic Acid
- Lithium Chloride
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Topics |
- Animals
- Appetite
(physiology)
- Association Learning
(physiology)
- Avoidance Learning
(physiology)
- Brain Mapping
- Conditioning, Classical
(physiology)
- Dietary Sucrose
(administration & dosage)
- Dose-Response Relationship, Drug
- Drinking
(physiology)
- Ibotenic Acid
- Lithium Chloride
(toxicity)
- Male
- Motivation
- Rats
- Rats, Sprague-Dawley
- Sodium, Dietary
(administration & dosage)
- Taste
(physiology)
- Thalamic Nuclei
(physiology)
- Water-Electrolyte Balance
(physiology)
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