Micronized flavonoid therapy in internal hemorrhoids of pregnancy.

Abstract

OBJECTIVE:

To assess the safety, efficacy and acceptability of a micronized flavonoid formulation in the treatment of internal hemorrhoids of pregnancy.

METHODS:

In an open study on hospital outpatients, we studied therapy with micronized diosmin 90% and hesperidin 10% for a median of 8 weeks before delivery and 4 weeks after delivery, in 50 women with acute hemorrhoids. The outcome measures were symptoms and signs of hemorrhoids; adverse effects; and acceptability of treatment.

RESULT:

On intention to treat analysis, 66% (95% confidence interval, range 79.1-52.9) had relief from acute symptoms by the 4th day; 53.6% (95% confidence interval, range 70-37.1, P < 0.001) fewer patients had relapse in the antenatal period. Treatment was well accepted, and did not affect pregnancy, fetal development, birth weight, infant growth and feeding.

CONCLUSION:

In the short term, micronized diosmin 90% and hesperidin 10% is safe, acceptable, and effective in the treatment of hemorrhoids of pregnancy.

• Authors: K Buckshee, D Takkar, N Aggarwal
• Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (Int J Gynaecol Obstet) Vol. 57 Issue 2 Pg. 145-51 (May 1997) ISSN: 0020-7292 [Print] United States
• PMID: 9184951 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Diosmin
• Hesperidin

Topics

• Acute Disease
• Administration, Oral
• Adult
• Chi-Square Distribution
• Confidence Intervals
• Diosmin (administration & dosage)
• Dose-Response Relationship, Drug
• Drug Compounding
• Female
• Hemorrhoids (drug therapy, etiology)
• Hesperidin (administration & dosage)
• Humans
• Pregnancy
• Pregnancy Complications (drug therapy)
• Pregnancy Outcome
• Prospective Studies
• Treatment Outcome