Abstract | OBJECTIVE: CASE SUMMARY: A 74-year-old white man with a history of probable complex partial seizures was admitted to the neurology service for a prolonged postictal state. His antiepileptic regimen was changed while he was in the hospital to include lamotrigine. After 19 days of hospitalization and 14 days of lamotrigine therapy, the patient became febrile. The next day he developed a rash which progressed within 4 days to TEN, diagnosed by skin biopsy. All suspected drugs were discontinued, including lamotrigine. The patient was treated with hydrotherapy in the burn unit. His symptoms improved and he was discharged from the hospital 26 days after the rash developed. DISCUSSION: CONCLUSIONS: Because of the temporal relationship of the onset of the patient's rash and several drugs that are known to cause severe rashes, it is not certain which drug was the definite culprit. However, based on the evidence from the literature, lamotrigine appears to be the causative agent.
|
Authors | J J Chaffin, S M Davis |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 31
Issue 6
Pg. 720-3
(Jun 1997)
ISSN: 1060-0280 [Print] United States |
PMID | 9184711
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- Anticonvulsants
- Triazines
- Lamotrigine
|
Topics |
- Aged
- Anticonvulsants
(adverse effects, therapeutic use)
- Humans
- Lamotrigine
- Male
- Seizures
(drug therapy)
- Stevens-Johnson Syndrome
(etiology)
- Triazines
(adverse effects, therapeutic use)
|