HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effect of vitamin B6 on the side effects of a low-dose combined oral contraceptive.

Abstract
Analogous to recommendations for treatment of side effects of early pregnancy and premenstrual syndrome, use of vitamin B6 has been recommended for the treatment of side effects of oral contraceptive (OC) use. A randomized, triple-blinded controlled trial of 124 women was done to evaluate the effect of taking 150 mg of vitamin B6 daily for 30 days on the severity of nausea, headache, vomiting, dizziness, depression, and irritability associated with the initiation of low-dose (30 micrograms norgestrel and 30 micrograms ethinyl estradiol) OG use. The severity of the symptoms was measured on a scale from 0 to 3 (not present to severe), and was evaluated at one month after admission. The two treatment groups (vitamin B, and placebo) had comparable baseline characteristics. From admission to follow up, there was a decrease in the severity of all symptoms in both groups. There was no statistically significant difference in the reductions found in the vitamin B6 and the placebo groups, although reductions in the severity of headache and dizziness were greater in the B6 group. The decrease in the severity of all OC side effects can be explained more by a placebo effect than by a marginal pharmacological effect of the vitamin B6.
AuthorsE Villegas-Salas, R Ponce de León, M A Juárez-Perez, G S Grubb
JournalContraception (Contraception) Vol. 55 Issue 4 Pg. 245-8 (Apr 1997) ISSN: 0010-7824 [Print] United States
PMID9179457 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Contraceptives, Oral, Combined
  • Placebos
  • Norgestrel
  • Ethinyl Estradiol
  • Pyridoxine
Topics
  • Adolescent
  • Adult
  • Contraceptives, Oral, Combined (adverse effects)
  • Dizziness
  • Ethinyl Estradiol (administration & dosage, adverse effects)
  • Female
  • Headache
  • Humans
  • Nausea
  • Norgestrel (administration & dosage, adverse effects)
  • Placebos
  • Pregnancy
  • Pyridoxine (administration & dosage, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: