Cutaneous heparin necrosis in a patient with heterozygous protein S deficiency.

Abstract

A patient with heterozygous protein S deficiency experienced cutaneous necrosis following subcutaneous heparin administration. Deficiencies of both protein C and protein S, known risk factors for the more frequently encountered coumarin necrosis, may predispose patients to this complication of heparin therapy as well. The putative association of protein S deficiency with cutaneous heparin necrosis could not be proven, however, since attempts to reproduce the heparin necrosis were unsuccessful.

• Authors: L F Libow, E A DiPreta, D L Dyksterhouse
• Journal: Cutis (Cutis) Vol. 59 Issue 5 Pg. 242-4 (May 1997) ISSN: 0011-4162 [Print] United States
• PMID: 9169261 (Publication Type: Case Reports, Journal Article)

Chemical References

• Heparin

Topics

• Abdomen
• Adult
• Female
• Heparin (administration & dosage, adverse effects)
• Heterozygote
• Humans
• Injections, Subcutaneous (adverse effects)
• Necrosis
• Protein C Deficiency
• Protein S Deficiency (complications, genetics)
• Risk Factors
• Skin Ulcer (etiology, pathology)