Abstract | OBJECTIVES: To determine the frequency and type of cardiac manifestations in children with systemic lupus erythematosus (SLE) and investigate whether cardiac involvement of SLE in children was associated with any autoantibody pattern. METHODS: Retrospective analysis of the medical records of all children with SLE (31 patients) seen between January 1984 and January 1994 by the paediatric rheumatology service at Children's Hospital in New Orleans. All patients satisfied the American College of Rheumatology criteria for the diagnosis of SLE. Paediatric SLE patients with cardiac manifestations based on echocardiogram were identified. Autoantibody tests at diagnosis were identified retrospectively by chart review, and the correlation between autoantibodies and cardiac involvement was analysed using the two tailed Fisher's exact test. RESULTS: CONCLUSIONS: Cardiac involvement in our paediatric SLE population was frequently found and correlated significantly with the presence of anti-Ro/SS-A and anti-La/SS-B antibodies.
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Authors | A C Oshiro, S J Derbes, A R Stopa, A Gedalia |
Journal | Annals of the rheumatic diseases
(Ann Rheum Dis)
Vol. 56
Issue 4
Pg. 272-4
(Apr 1997)
ISSN: 0003-4967 [Print] England |
PMID | 9166002
(Publication Type: Journal Article)
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Chemical References |
- Autoantibodies
- Autoantigens
- RNA, Small Cytoplasmic
- RO60 protein, human
- Ribonucleoproteins
- SS-A antigen
- SS-B antigen
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Topics |
- Adolescent
- Autoantibodies
(blood)
- Autoantigens
(immunology)
- Child
- Child, Preschool
- Echocardiography
- Female
- Humans
- Lupus Erythematosus, Systemic
(diagnostic imaging, immunology)
- Male
- Pericarditis
(diagnostic imaging, immunology)
- RNA, Small Cytoplasmic
- Retrospective Studies
- Ribonucleoproteins
(immunology)
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