Abstract |
CMP-NeuAc: Galbeta1,3(4)GlcNAc alpha2,3-sialyltransferase (alpha2,3-ST) mRNA was expressed in human glioma specimens, human fetal astrocytes, and a panel of brain tumor cell lines. Maackia amurensis agglutinin staining revealed the presence of alpha2,3-linked sialic acids on glioma cell surfaces and extracellular matrices whereas normal human adult astrocytes were negative. Increased expression of alpha2,3-linked glycoprotein sialylation may play a role in glial tumorigenesis.
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Authors | H Yamamoto, T Saito, Y Kaneko, D Kersey, V W Yong, E G Bremer, E Mkrdichian, L Cerullo, J Leestma, J R Moskal |
Journal | Brain research
(Brain Res)
Vol. 755
Issue 1
Pg. 175-9
(Apr 25 1997)
ISSN: 0006-8993 [Print] Netherlands |
PMID | 9163557
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Glycoproteins
- RNA, Messenger
- Sialyltransferases
- beta-Galactoside alpha-2,3-Sialyltransferase
- ST3GAL1 protein, human
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Topics |
- Adenocarcinoma
(metabolism)
- Astrocytes
(metabolism)
- Astrocytoma
(metabolism)
- Brain Neoplasms
(metabolism, secondary)
- Carbohydrate Conformation
- Glioblastoma
(metabolism)
- Glioma
(metabolism)
- Glycoproteins
(metabolism)
- Humans
- RNA, Messenger
(metabolism)
- Sialyltransferases
(genetics)
- Tumor Cells, Cultured
- beta-Galactoside alpha-2,3-Sialyltransferase
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