HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

alpha2,3-sialyltransferase mRNA and alpha2,3-linked glycoprotein sialylation are increased in malignant gliomas.

Abstract
CMP-NeuAc: Galbeta1,3(4)GlcNAc alpha2,3-sialyltransferase (alpha2,3-ST) mRNA was expressed in human glioma specimens, human fetal astrocytes, and a panel of brain tumor cell lines. Maackia amurensis agglutinin staining revealed the presence of alpha2,3-linked sialic acids on glioma cell surfaces and extracellular matrices whereas normal human adult astrocytes were negative. Increased expression of alpha2,3-linked glycoprotein sialylation may play a role in glial tumorigenesis.
AuthorsH Yamamoto, T Saito, Y Kaneko, D Kersey, V W Yong, E G Bremer, E Mkrdichian, L Cerullo, J Leestma, J R Moskal
JournalBrain research (Brain Res) Vol. 755 Issue 1 Pg. 175-9 (Apr 25 1997) ISSN: 0006-8993 [Print] Netherlands
PMID9163557 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Glycoproteins
  • RNA, Messenger
  • Sialyltransferases
  • beta-Galactoside alpha-2,3-Sialyltransferase
  • ST3GAL1 protein, human
Topics
  • Adenocarcinoma (metabolism)
  • Astrocytes (metabolism)
  • Astrocytoma (metabolism)
  • Brain Neoplasms (metabolism, secondary)
  • Carbohydrate Conformation
  • Glioblastoma (metabolism)
  • Glioma (metabolism)
  • Glycoproteins (metabolism)
  • Humans
  • RNA, Messenger (metabolism)
  • Sialyltransferases (genetics)
  • Tumor Cells, Cultured
  • beta-Galactoside alpha-2,3-Sialyltransferase

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: