Maternal inheritance of atopy at the Fc epsilon RI beta locus in Japanese sibs.

Abstract

Twenty-four Japanese atopic sibs with asthma and/or rhinitis were tested for polymorphic microsatellite repeats of Fc epsilon RI beta on chromosome 11q13. Significantly increased sharing of maternal alleles was found chi 2 = 5.86, p < 0.025) while no significant sharing was found for paternal alleles. These findings confirm maternal inheritance of atopy at this locus in a non-Caucasian population.

• Authors: X O Mao, T Shirakawa, S Sasaki, T Enomoto, K Morimoto, J M Hopkin
• Journal: Human heredity (Hum Hered) 1997 May-Jun Vol. 47 Issue 3 Pg. 178-80 ISSN: 0001-5652 [Print] Switzerland
• PMID: 9156331 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptors, IgE

Topics

• Asthma (genetics)
• Chromosomes, Human, Pair 11
• Dinucleotide Repeats (genetics)
• Female
• Humans
• Hypersensitivity, Immediate (genetics)
• Japan
• Nuclear Family
• Polymorphism, Genetic
• Receptors, IgE (genetics)
• Rhinitis (genetics)