Listeria endocarditis: current management and patient outcome--world literature review.

Abstract

This is believed to be the 58th reported case of Listeria monocytogenes infective endocarditis. Published reports worldwide were reviewed as to treatment, outcome, and prognostic features. There is controversy over whether all patients with this condition should have surgery. Moreover the best antibiotic treatment is not known, which accounts for the heterogeneity of regimens used. Listeria endocarditis has a high mortality rate (37%). This was higher in men (41% v 32%) and in patients with valve prostheses (41% v 31%), though neither observation reached statistical significance. There was no significant difference in mortality between surgical and non-surgical treatment, but untreated listeria endocarditis proved universally fatal. From the data, treatment with ampicillin is recommended, with resort to surgery in cases where the infection cannot be eradicated or where haemodynamic compromise has occurred.

• Authors: N Spyrou, M Anderson, R Foale
• Journal: Heart (British Cardiac Society) (Heart) Vol. 77 Issue 4 Pg. 380-3 (Apr 1997) ISSN: 1355-6037 [Print] England
• PMID: 9155624 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Anti-Bacterial Agents
• Gentamicins
• Ampicillin

Topics

• Aged
• Ampicillin (therapeutic use)
• Anti-Bacterial Agents (therapeutic use)
• Endocarditis, Bacterial (drug therapy)
• Female
• Gentamicins (therapeutic use)
• Humans
• Listeriosis (drug therapy)
• Prosthesis-Related Infections (drug therapy)