HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

High incidence of pre-excitation syndrome in Japanese families with Leber's hereditary optic neuropathy.

Abstract
Cardiac conduction abnormalities have been reported in families with Leber's hereditary optic neuropathy (LHON). The pre-excitation syndrome Wolff-Parkinson-White syndrome or Lown-Ganong-Levine syndrome, is reportedly common in Finns with LHON, being seen in 14 (9%) of the 163 individuals with mitochondrial DNA (mtDNA) mutations. While this syndrome is thought to be rare in other ethnic groups with LHON, the present study of 35 Japanese LHON families confirmed that it is also relatively common among Japanese families, being seen in 5 (8%) of the 63 individuals with mtDNA mutations. It remains to be determined whether the high incidence of the pre-excitation syndrome in Finnish and Japanese LHON families is due to a particular genetic composition of ethnic groups such as in Finland and in Japan, or only to a reporting bias.
AuthorsY Mashima, K Kigasawa, H Hasegawa, M Tani, Y Oguchi
JournalClinical genetics (Clin Genet) Vol. 50 Issue 6 Pg. 535-7 (Dec 1996) ISSN: 0009-9163 [Print] Denmark
PMID9147893 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • DNA, Mitochondrial
Topics
  • Comorbidity
  • DNA, Mitochondrial (genetics)
  • Female
  • Finland (epidemiology)
  • Humans
  • Incidence
  • Japan (epidemiology)
  • Male
  • Optic Atrophies, Hereditary (ethnology)
  • Wolff-Parkinson-White Syndrome (ethnology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: