Abstract |
In the cerebrospinal fluid (CSF) of 53 patients with senile dementia of the Alzheimer type (SDAT) and 12 elderly controls, we measured somatostatin (SLI) and its molecular forms: high-molecular weight form (HMV-SST), somatostatin-14 (SST-14), somatostatin-25/28 (SST-28/25), and des-ala- somatostatin (des-ala-SST) using high pressure liquid chromatography (HPLC) and a radioimmunoassay. In SDAT, SLI was significantly decreased (p < 0.05) and correlated with dementia scores (r = -0.65, p < 0.05). HPLC separation showed a marked heterogeneity of SLI in the CSF with a preponderance of SST-14 and SST-25/28. The significant loss of SST-14 (p < 0.05) in SDAT was found to be correlated with dementia scores (r = 0.65). Moreover, qualitative and quantitative changes in the molecular pattern of SLI in SDAT indicated dysregulated synthesis and/or processing of somatostatin relating to the severity of dementia. The long-term administration of neuroleptics in severe cases of SDAT caused a significant increase of SLI (p < 0.05) and influenced the ratio of HMV-SST/SST-14 and SST25/28/SST-14.
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Authors | M Strittmatter, H Cramer, C Reuner, D Strubel, G Hamann, K Schimrigk |
Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 41
Issue 11
Pg. 1124-30
(Jun 01 1997)
ISSN: 0006-3223 [Print] United States |
PMID | 9146823
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antipsychotic Agents
- Somatostatin
- Chlorpromazine
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Topics |
- Aged
- Alzheimer Disease
(cerebrospinal fluid, drug therapy)
- Antipsychotic Agents
(administration & dosage, pharmacology, therapeutic use)
- Chlorpromazine
(administration & dosage, pharmacology, therapeutic use)
- Chromatography, High Pressure Liquid
- Cognition Disorders
(diagnosis)
- Cross Reactions
- Female
- Humans
- Male
- Molecular Weight
- Somatostatin
(biosynthesis, cerebrospinal fluid)
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