Protective effect of liposomal gentamicin against systemic acute murine brucellosis.

Abstract

Liposomes of the stable multilamellar type, which previously demonstrated great efficiency in antibiotic transport [Vitas et al: Antimicrob Agents Chemother 1996;40:146-151] were used in this study as carriers of gentamicin for treatment of mice lethally infected with Brucella abortus. Treatment with gentamicin in positively charged liposomes produced a protective effect when it was administered 1 day after lethal challenge (70% of protection). On the other hand, the use of free gentamicin or in liposomes with a negative net charge did not produce a protective effect. Moreover, the results reported here also indicated that cationic liposomes themselves had a therapeutic effect on the course of the infection (up to 50% of protection). In conclusion, we observed that cationic liposomal encapsulation of gentamicin resulted in an enhancement of the therapeutic activity of free gentamicin in this mouse model of acute infection.

• Authors: A I Vitas, R Díaz, C Gamazo
• Journal: Chemotherapy (Chemotherapy) 1997 May-Jun Vol. 43 Issue 3 Pg. 204-10 ISSN: 0009-3157 [Print] Switzerland
• PMID: 9142462 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Gentamicins
• Liposomes

Topics

• Animals
• Anti-Bacterial Agents (pharmacology, therapeutic use)
• Brucella abortus (drug effects, metabolism)
• Brucellosis (drug therapy)
• Drug Delivery Systems
• Female
• Gentamicins (pharmacology, therapeutic use)
• Injections, Intraperitoneal
• Liposomes
• Mice
• Mice, Inbred Strains