Abstract | BACKGROUND: Intestinal ischemic injury is exacerbated by reperfusion in rodent and feline models because of xanthine oxidase-initiated reactive oxygen metabolite formation and neutrophil infiltration. Studies were conducted to determine the relevance of reperfusion injury in the juvenile pig, whose low levels of xanthine oxidase are similar to those of the human being. METHODS: RESULTS: Significant ischemic injury was evident after 0.5 to 3 hours of complete mesenteric occlusion or 2 hours of shock or volvulus. In none of these models was the ischemic injury worsened by reperfusion. To maximize superoxide production, pigs were ventilated on 100% O2, but only limited reperfusion injury (1.2-fold increase in histologic grade) was noted. Xanthine oxidase- xanthine dehydrogenase levels were negligible (0.4 +/- 0.4 mU/gm). CONCLUSIONS:
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Authors | A T Blikslager, M C Roberts, J M Rhoads, R A Argenzio |
Journal | Surgery
(Surgery)
Vol. 121
Issue 5
Pg. 526-34
(May 1997)
ISSN: 0039-6060 [Print] United States |
PMID | 9142151
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Peroxidases
- Xanthine Dehydrogenase
- Xanthine Oxidase
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Topics |
- Animals
- Female
- Intestinal Mucosa
(enzymology, pathology)
- Intestines
(blood supply, enzymology)
- Ischemia
(complications, metabolism)
- Male
- Peroxidases
(metabolism)
- Reperfusion Injury
(complications, metabolism)
- Swine
- Xanthine Dehydrogenase
(metabolism)
- Xanthine Oxidase
(metabolism)
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