Ulcerating necrobiosis lipoidica resolving in response to cyclosporine-A.

Abstract

Necrobiosis lipoidica often fails to respond adequately to therapy with topical and intralesional corticosteroids, or to systemic medications like niacinamide and pentoxifylline (Trental). On the basis of unpublished work which showed a predominance of T helper cells in lesions of necrobiosis lipoidica, and recalling the case of a woman whose necrobiosis lipoidica improved after she was started on cyclosporine for a renal transplant, systemic cyclosporine was successfully used in the cases of two young women who had insulin-dependent diabetes and were disfigured by severe, ulcerating necrobiosis lipoidica on the anterior lower legs. Response to treatment was monitored with photographs. In both cases the ulcers resolved, and remained in remission after cyclosporine was stopped.

• Authors: K Smith
• Journal: Dermatology online journal (Dermatol Online J) Vol. 3 Issue 1 Pg. 2 (Mar 1997) ISSN: 1087-2108 [Electronic] United States
• PMID: 9141363 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antirheumatic Agents
• Cyclosporine

Topics

• Adult
• Antirheumatic Agents (therapeutic use)
• Cyclosporine (therapeutic use)
• Diabetes Mellitus, Type 1 (complications)
• Female
• Humans
• Necrobiosis Lipoidica (drug therapy, etiology)