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Antagonism of suxamethonium-induced jaw muscle contracture in rats.

Abstract
Masseter muscle rigidity (MMR) induced during general anaesthesia by suxamethonium is a clinical problem that may interfere with tracheal intubation. We have investigated the relation between twitch tension and contracture response to suxamethonium in rats. Rats were anaesthetized with 1% halothane (1.35 MAC). Jaw muscle temperature was maintained at either 37 or 41 degrees C while rectal temperature was kept at 37 degrees C by radiant heat. Twitch tension was produced by nerve stimulation at 0.2 Hz. Rats were pretreated with either a low dose of vecuronium (0.03 mg kg-1) or dantrolene (0.8 mg kg-1). Thereafter suxamethonium 750 micrograms kg-1 was administrated i.v. Low-dose vecuronium pretreatment significantly (90%) decreased suxamethonium-induced jaw muscle contracture (JMC) with minimal (3%) twitch block during local hyperthermia. Low-dose dantrolene pretreatment also reduced JMC (81% at 37 degrees C and 82% at 41 degrees C) while decreasing twitch by 30% at 37 degrees C and 31% at 41 degrees C. Both vecuronium and dantrolene at doses that minimally depressed the twitch response antagonized suxamethonium-induced JMC. We speculate that pretreatment with low-dose vecuronium decreases suxamethonium-induced MMR clinically.
AuthorsY Shi, R J Storella, M M Keykhah, H Rosenberg
JournalBritish journal of anaesthesia (Br J Anaesth) Vol. 78 Issue 3 Pg. 332-3 (Mar 1997) ISSN: 0007-0912 [Print] England
PMID9135319 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Muscle Relaxants, Central
  • Neuromuscular Depolarizing Agents
  • Neuromuscular Nondepolarizing Agents
  • Vecuronium Bromide
  • Dantrolene
  • Succinylcholine
Topics
  • Animals
  • Dantrolene (therapeutic use)
  • Male
  • Malignant Hyperthermia (complications)
  • Masseter Muscle (drug effects)
  • Muscle Relaxants, Central (therapeutic use)
  • Muscle Rigidity (etiology, prevention & control)
  • Neuromuscular Depolarizing Agents (antagonists & inhibitors, toxicity)
  • Neuromuscular Nondepolarizing Agents (therapeutic use)
  • Rats
  • Rats, Inbred WF
  • Succinylcholine (antagonists & inhibitors, toxicity)
  • Vecuronium Bromide (therapeutic use)

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