Abstract |
Masseter muscle rigidity (MMR) induced during general anaesthesia by suxamethonium is a clinical problem that may interfere with tracheal intubation. We have investigated the relation between twitch tension and contracture response to suxamethonium in rats. Rats were anaesthetized with 1% halothane (1.35 MAC). Jaw muscle temperature was maintained at either 37 or 41 degrees C while rectal temperature was kept at 37 degrees C by radiant heat. Twitch tension was produced by nerve stimulation at 0.2 Hz. Rats were pretreated with either a low dose of vecuronium (0.03 mg kg-1) or dantrolene (0.8 mg kg-1). Thereafter suxamethonium 750 micrograms kg-1 was administrated i.v. Low-dose vecuronium pretreatment significantly (90%) decreased suxamethonium-induced jaw muscle contracture (JMC) with minimal (3%) twitch block during local hyperthermia. Low-dose dantrolene pretreatment also reduced JMC (81% at 37 degrees C and 82% at 41 degrees C) while decreasing twitch by 30% at 37 degrees C and 31% at 41 degrees C. Both vecuronium and dantrolene at doses that minimally depressed the twitch response antagonized suxamethonium-induced JMC. We speculate that pretreatment with low-dose vecuronium decreases suxamethonium-induced MMR clinically.
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Authors | Y Shi, R J Storella, M M Keykhah, H Rosenberg |
Journal | British journal of anaesthesia
(Br J Anaesth)
Vol. 78
Issue 3
Pg. 332-3
(Mar 1997)
ISSN: 0007-0912 [Print] England |
PMID | 9135319
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Muscle Relaxants, Central
- Neuromuscular Depolarizing Agents
- Neuromuscular Nondepolarizing Agents
- Vecuronium Bromide
- Dantrolene
- Succinylcholine
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Topics |
- Animals
- Dantrolene
(therapeutic use)
- Male
- Malignant Hyperthermia
(complications)
- Masseter Muscle
(drug effects)
- Muscle Relaxants, Central
(therapeutic use)
- Muscle Rigidity
(etiology, prevention & control)
- Neuromuscular Depolarizing Agents
(antagonists & inhibitors, toxicity)
- Neuromuscular Nondepolarizing Agents
(therapeutic use)
- Rats
- Rats, Inbred WF
- Succinylcholine
(antagonists & inhibitors, toxicity)
- Vecuronium Bromide
(therapeutic use)
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