Renal tubular abnormalities in hydrops fetalis: a histological and immunohistochemical study.

Abstract

An immunohistochemical study of renal tubule cell differentiation in hydrops fetalis was performed using antibodies against lysozyme, CD15, keratin, epithelial membrane antigen and Leu-7, and formalin-fixed, paraffin-embedded sections of tissue that was obtained at autopsy. In 3 cases among 17 cases of hydrops fetalis (17.6%) there was a marked decrease in the number of cells stained positively for lysozyme, suggesting abnormal differentiation of the cells of the proximal convoluted tubules. This is the first report concerning the abnormalities of the renal tubular epithelium in hydrops fetalis.

• Authors: H Endo, T Oka
• Journal: Early human development (Early Hum Dev) Vol. 48 Issue 1-2 Pg. 11-21 (Apr 25 1997) ISSN: 0378-3782 [Print] Ireland
• PMID: 9131303 (Publication Type: Journal Article)

Chemical References

• CD57 Antigens
• Lewis X Antigen
• Mucin-1
• Keratins
• Muramidase

Topics

• CD57 Antigens (analysis)
• Cell Differentiation
• Epithelium (pathology)
• Female
• Fetal Death
• Gestational Age
• Humans
• Hydrops Fetalis (complications, mortality)
• Immunohistochemistry
• Keratins (analysis)
• Kidney Tubules (abnormalities, pathology)
• Lewis X Antigen (analysis)
• Male
• Mucin-1 (analysis)
• Muramidase (analysis)