Analysis of asbestos bodies in BAL from subjects with particular exposures.

Four patients with asbestos-related diseases and with unusual exposures underwent bronchoalveolar lavage (BAL) for mineralogical analysis. Asbestos bodies (AB) were counted by light microscopy and analyzed by transmission electron microscopy and X-ray energy spectrometry. AB's were found in all cases, after a mean delay from the end of exposure of 27.7 years. Analysis of the core fibers indicated the type of alveolar asbestos burden and was compared with the previous exposures: Pleural plaques due to household exposure to amosite and crocidolite. Pleural plaques due to occult occupational exposure to crocidolite in a coal miner. Asbestosis due to environmental exposure to tremolite in Turkey. Asbestosis, pleural plaques, and peritoneal mesothelioma due to a short, intense exposure to crocidolite. AB counting in BAL and identification of the central fibers by analytical electron microscopy is a useful, non-invasive and reliable method to evaluate the alveolar retention of bio-persistent fibers and to relate them to specific exposures.
AuthorsP De Vuyst, P Dumortier, P A Gevenois
JournalAmerican journal of industrial medicine (Am J Ind Med) Vol. 31 Issue 6 Pg. 699-704 (Jun 1997) ISSN: 0271-3586 [Print] UNITED STATES
PMID9131224 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Mineral Fibers
  • Asbestos
  • Aged
  • Asbestos (analysis)
  • Bronchoalveolar Lavage Fluid (chemistry)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mineral Fibers (analysis)
  • Occupational Exposure
  • Pleural Diseases (etiology)
  • Pulmonary Alveoli

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