Evaluation of gestrinone after surgery in treatment of endometriosis.

The clinical and histological efficacy of gestrinone in the treatment of endometriosis was evaluated.
A prospective study was performed with longitudinal follow-up of 4 years duration (minimum) for each patient. Twenty-five cases of endometriosis were treated with gestrinone (as a drug of choice or associated with other local surgical treatment) during 6 months.
The total or partial response to pain was induced with treatment in 19 of the 20 cases (95%), and posttreatment pregnancies were induced in 3 of the 9 cases of infertility (33.3%). The global clinical efficacy was as follows: none (n = 5, 20%), poor (n = 2, 8%), moderate (n = 2, 8%), good (n = 3, 12%) and excellent (n = 13, 52%). The pretreatment American Fertility Society score was 23.1 +/- 3.8 points (2-58) and that after treatment (re-examination) 7.8 +/- 3.7 points (0-52), p < 0.01. Global histological efficacy (n = 17) results were as follows: none (23.6%), poor (0%), moderate (5.8%), good (35.3%) and excellent (35.3%).
Gestrinone is presented as a drug with an efficacy comparable to other pharmacological agents currently available in the medical treatment of endometriosis. Adequate posology and acceptable effectiveness were also observed.
AuthorsA Nieto, C Tacuri, M Serra, J Keller, J Cortés-Prieto
JournalGynecologic and obstetric investigation (Gynecol Obstet Invest) Vol. 43 Issue 3 Pg. 192-4 ( 1997) ISSN: 0378-7346 [Print] SWITZERLAND
PMID9127134 (Publication Type: Journal Article)
Chemical References
  • Progesterone Congeners
  • Gestrinone
  • Abdominal Pain (therapy)
  • Adult
  • Analgesia
  • Combined Modality Therapy
  • Endometriosis (drug therapy, surgery)
  • Female
  • Gestrinone (therapeutic use)
  • Humans
  • Pregnancy
  • Progesterone Congeners (therapeutic use)
  • Prospective Studies
  • Recurrence

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