[Subclinical pro-thrombotic state in a relapse of Behcet's disease--case report].

Abstract

A patient, aged 34, with a relapse of Behcet's disease (BD) showed laboratory features of enhanced coagulation activation without any symptoms of arterial or venous thrombosis. Elevated levels of thrombin-antithrombin III complexes (TAT), prothrombin fragments 1 + 2 (F1 + 2), associated with impairement of fibrinolysis were found. Total fibrinolytic activity, measured on fibrin plates, plasma concentration of tissue-type plasminogen activator (tPA:Ag) and plasmin-alpha 2-antiplasmin complexes (PAP) were low, whereas plasminogen activator inhibitor 1 concentration (PAI-1:Ag) was elevated in comparison with normal values. There intravenous 500 mg doses of cyclophosphamide, given on day 0, 7 and 50, resulted in a marked clinical improvement. This was accompanied by the normalization of augmented thrombin generation and increased fibrinolytic activity. This is the first report to show prothrombotic tendency in a relapse of Behcet disease and beneficial effect of cyclophosphamide therapy on haemostatic abnormalities. A degree of activation of coagulative and fibrinolytic system seems to be of importance in the pathogenesis of Behcet's disease, and monitoring of hemostatic parameters could be helpful in clinical assessment.

• Authors: A Undas, G Pinis
• Journal: Polskie Archiwum Medycyny Wewnetrznej (Pol Arch Med Wewn) Vol. 96 Issue 3 Pg. 258-62 (Sep 1996) Poland
• Vernacular Title: Subkliniczny stan prozakrzepowy w zaostrzeniu choroby Behceta--opis przypadku.
• PMID: 9122017 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Cyclophosphamide

Topics

• Adult
• Behcet Syndrome (complications, physiopathology)
• Blood Coagulation Disorders (diagnosis, drug therapy, etiology)
• Cyclophosphamide (therapeutic use)
• Hemostasis (drug effects, physiology)
• Humans
• Male
• Recurrence