Antitumour and anti-AIDS triterpenes from Celastrus hindsii.

Abstract

Four new triterpene compounds, celasdin-A, celasdin-C, anti-AIDS celasdin-B and cytotoxic maytenfolone-A, were isolated from Celastrus hindsii. The structural determination of maytenfolone-A, celasdin-A, celasdin-B and celasdin-C, as well as the structure-activity relationships of these new compounds and derivatives, are discussed. Maytenfolone-A was further confirmed by X-ray studies. Biological evaluation showed that Maytenfolone-A demonstrated cytotoxicity against hepatoma (HEPA-2B, ED50 = 2.3 micrograms ml-1) and nasopharynx carcinoma (KB, ED50 = 3.8 micrograms ml-1). Celasdin-B was found to exhibit anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 0.8 microgram ml-1).

• Authors: Y H Kuo, L M Kuo
• Journal: Phytochemistry (Phytochemistry) Vol. 44 Issue 7 Pg. 1275-81 (Apr 1997) ISSN: 0031-9422 [Print] England
• PMID: 9115698 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-HIV Agents
• Antineoplastic Agents, Phytogenic
• Triterpenes

Topics

• Anti-HIV Agents (isolation & purification, pharmacology)
• Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology)
• HIV (drug effects, physiology)
• Humans
• Magnetic Resonance Spectroscopy
• Plants (chemistry)
• Triterpenes (isolation & purification, pharmacology)
• Tumor Cells, Cultured
• Virus Replication (drug effects)