[Effects of diphtheria and tetanus toxins on liver regeneration in the rat].

Abstract

The effects of diphtheria toxin and tetanus toxin on the regenerating rat liver were studied. The following parameters were used: liver regeneration percentage, mitotic index, protein content and serum complement C3 fraction level. Diphtheria toxin does not affect the liver regeneration, that what confirms the poor sensitivity of the rat to this toxin. Tetanus toxin inhibits the cellular division, while causes an increase in the cell protein content, resulting in hepatocyte hypertrophy. Both toxins cause a fall of the serum complement C3 fraction.

• Authors: A Rossolini, C Cellesi, V Del Ministro, A Barberi, F L Pasini, A Auteri
• Journal: Bollettino dell'Istituto sieroterapico milanese (Boll Ist Sieroter Milan) Vol. 56 Issue 4 Pg. 387-90 (Sep 1977) ISSN: 0021-2547 [Print] Italy
• Vernacular Title: Effetti delle tossine difterica e tetanica sulla rigenerazione epatica nel ratto.
• PMID: 911466 (Publication Type: English Abstract, Journal Article)

Chemical References

• Complement C3
• Diphtheria Toxin
• Tetanus Toxin

Topics

• Animals
• Cell Division (drug effects)
• Complement C3 (physiology)
• Diphtheria Toxin (pharmacology)
• Female
• Liver Regeneration (drug effects)
• Mitosis (drug effects)
• Rats
• Tetanus Toxin (pharmacology)