Topical ibopamine and corticosteroids in the treatment of post-surgery ocular hypotony.

Abstract

PURPOSE:

The aim of the present preliminary study, performed on post-surgical hypotony, was the evaluation of the effects on ocular hypotony of the concomitant administration of ibopamine and corticosteroids.

METHODS:

14 patients (11 males-3 females; mean age 47 years) with ocular hypotony following several vitroretinal surgical intervention in different districts, were enrolled. The inclusion criteria were: mean IOP during tonometric curve equal or lower than 6 mmHg, stable IOP for at least 60 days, ongoing treatment with 0.1% dexamethasone (4 times/day), successful surgical intervention, 2% ibopamine (4 times/day) was added to the corticosteroid therapy for 30-60 days.

RESULTS:

Before ibopamine administration, mean IOP was 4.07 mmHg SD 1.71. At the end of the treatment period, mean IOP increased by 89% in comparison to baseline values (+ 3.64 mmHg SD 5.57). This difference was statistically significant (paired t = 2.39; P = 0.03). One month after ibopamine-treatment discontinuation, mean IOP decreased to pre-treatment values (4.86 mmHg SD 3.50).

CONCLUSIONS:

The results of the present study, although preliminary, suggest the possibility of a future pharmacological treatment of ocular hypotony with ibopamine, whose rationale is based on the increase of aqueous humor production by stimulating the D1 dopaminergic receptor.

• Authors: M Virno, F De Gregorio, L Pannarale, L Arrico
• Journal: International ophthalmology (Int Ophthalmol) 1996-1997 Vol. 20 Issue 1-3 Pg. 147-50 ISSN: 0165-5701 [Print] Netherlands
• PMID: 9112179 (Publication Type: Journal Article)

Chemical References

• Dopamine Agonists
• Glucocorticoids
• Ophthalmic Solutions
• Receptors, Dopamine D1
• Dexamethasone
• ibopamine
• Deoxyepinephrine

Topics

• Administration, Topical
• Adult
• Aged
• Aqueous Humor (metabolism)
• Deoxyepinephrine (administration & dosage, analogs & derivatives, therapeutic use)
• Dexamethasone (administration & dosage, therapeutic use)
• Dopamine Agonists (administration & dosage, therapeutic use)
• Drug Therapy, Combination
• Female
• Follow-Up Studies
• Glucocorticoids (administration & dosage, therapeutic use)
• Humans
• Intraocular Pressure (drug effects)
• Male
• Middle Aged
• Ocular Hypotension (drug therapy, etiology, physiopathology)
• Ophthalmic Solutions
• Postoperative Complications (drug therapy, etiology, physiopathology)
• Receptors, Dopamine D1 (agonists)
• Treatment Outcome