Involvement of cytokines in cachexia induced by T-cell leukaemia in the rat.

Abstract

The objective of this study was to investigate the involvement of cytokines (IL-1, IL-6 and TNF-alpha) in cachexia induced by T-cell leukaemia in the rat. Leukaemic rats exhibited a marked and significant increase in circulating IL-6 concentration from days 12-17 corresponding to the period of weight loss after induction of leukaemia. IL-6 plasma bioactivity correlated significantly with spleen weight and weight loss, implicating IL-6 in the cachectic response. In contrast, IL-1 and TNF-alpha plasma bioactivities were not increased compared to control rats, indicating that these cytokines are not circulating mediators of cachexia induced by T-cell leukaemia in the rat. These data suggest that IL-6 produced by the host may contribute to cachexia induced by T-cell leukaemia.

• Authors: S Y Roe, A L Cooper, I D Morris, S J Hopkins, N J Rothwell
• Journal: European cytokine network (Eur Cytokine Netw) Vol. 8 Issue 1 Pg. 45-9 (Mar 1997) ISSN: 1148-5493 [Print] France
• PMID: 9110147 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-1
• Interleukin-6
• Tumor Necrosis Factor-alpha

Topics

• Animals
• Cachexia (etiology, metabolism)
• Interleukin-1 (blood, physiology)
• Interleukin-6 (blood, physiology)
• Leukemia, T-Cell (complications, metabolism)
• Male
• Rats
• Tumor Necrosis Factor-alpha (physiology)