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Focal nodular hyperplasia of the liver: serial MRI with Gd-DOTA, superparamagnetic iron oxide, and Gd-EOB-DTPA.

AbstractBACKGROUND:
To demonstrate the improved specificity of liver MRI in diagnosis of focal nodular hyperplasia (FNH) using liver specific contrast agents.
METHODS:
In a patient after resected adenosarcoma of the uterus a focal nodular hyperplasia was followed. Serial MRI of the liver was performed using first Gd-DOTA, followed by superparamagnetic iron oxide (SPIO) as well as Gd-EOB-DTPA.
RESULTS:
During the follow-up of FNH specificity of liver MRI improved using liver specific contrast agents. The central scar as well as the pseudocapsule showed different typical contrast uptake using all three methods.
CONCLUSION:
Serial MRI of the liver with Gd-DOTA, SPIO and Gd-EOB-DTPA can exclude a malignant liver lesion. Liver biopsy of FNH can be avoided with increased specificity of MRI for FNH.
AuthorsG M Kacl, K D Hagspiel, B Marincek
JournalAbdominal imaging (Abdom Imaging) 1997 May-Jun Vol. 22 Issue 3 Pg. 264-7 ISSN: 0942-8925 [Print] United States
PMID9107647 (Publication Type: Case Reports, Clinical Trial, Clinical Trial, Phase III, Journal Article)
Chemical References
  • Contrast Media
  • Dextrans
  • Heterocyclic Compounds
  • Magnetite Nanoparticles
  • Organometallic Compounds
  • Oxides
  • Suspensions
  • gadolinium ethoxybenzyl DTPA
  • Pentetic Acid
  • gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate
  • Gadolinium
  • Iron
  • ferumoxides
  • Gadolinium DTPA
  • Ferrosoferric Oxide
Topics
  • Adult
  • Contrast Media
  • Dextrans
  • Female
  • Ferrosoferric Oxide
  • Gadolinium
  • Gadolinium DTPA
  • Heterocyclic Compounds
  • Humans
  • Hyperplasia
  • Iron
  • Liver (pathology)
  • Liver Diseases (diagnosis)
  • Magnetic Resonance Imaging (methods)
  • Magnetite Nanoparticles
  • Organometallic Compounds
  • Oxides
  • Pentetic Acid (analogs & derivatives)
  • Suspensions

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