Agyria-pachygyria: cerebral perfusion studies by 99mTc-HMPAO SPECT [corrected].

Abstract	Cerebral perfusion was investigated in three patients with agyria-pachygyria by using 99mTc-HMPAO SPECT in order to study the distribution of blood flow. Diffuse cortical hypoperfusion was found in all three infants. The visual cortex was not identifiable in two of the cases. The basal ganglia and cerebellum were prominent by their normal high activity, while tracer uptake was very low in the thalamus. The possible role of improper development of interneuronal connections and abnormal vascular pattern in background of the perfusion defect is discussed.
Authors	A R al-Suhaili, L Sztriha, V Prais, M Nork
Journal	Brain & development (Brain Dev) Vol. 19 Issue 2 Pg. 138-43 (Mar 1997) ISSN: 0387-7604 [Print] Netherlands
PMID	9105662 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Organotechnetium Compounds Oximes Technetium Tc 99m Exametazime
Topics	Cerebral Cortex (abnormalities, anatomy & histology, blood supply) Cerebrovascular Circulation (physiology) Child, Preschool Electroencephalography Female Humans Infant, Newborn Magnetic Resonance Imaging Male Organotechnetium Compounds Oximes Technetium Tc 99m Exametazime Tomography, Emission-Computed, Single-Photon Tomography, X-Ray Computed

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