[Multiple organ failure after severe trauma: predictable by the MEGX liver function test?].

Abstract

The prognostic value of a dynamic liver-function test, based on the hepatic conversion of lidocaine to monoethylglycinexylidide (MEGX), in predicting multiple organ failure (MOF) was prospectively investigated in 28 critically ill patients after multiple trauma. The MEGX test and conventional static liver tests (bilirubin, aspartate aminotransferase, glutamate dehydrogenase and factor V) were performed on days 1, 3, 5, and 7 after trauma and patients were classified by a modified MOF score into a group without (n = 18) and a group with the MOF syndrome (n = 9). All patients who subsequently developed MOF, however, displayed a sharp decrease in their MEGX values between days 1 and 3.

• Authors: D Pape, U Lehmann, M Oellerich, G Regel
• Journal: Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress (Langenbecks Arch Chir Suppl Kongressbd) Vol. 113 Pg. 338-9 ( 1996) ISSN: 0942-2854 [Print] Germany
• Vernacular Title: Multiples Organversagen nach schwerem Trauma: vorhersagbar durch den Leberfunktionstest MEGX?
• PMID: 9101869 (Publication Type: Journal Article)

Chemical References

• Lidocaine
• monoethylglycinexylidide
• Aspartate Aminotransferases
• Alanine Transaminase

Topics

• Alanine Transaminase (blood)
• Aspartate Aminotransferases (blood)
• Critical Care
• Humans
• Injury Severity Score
• Lidocaine (analogs & derivatives, pharmacokinetics)
• Liver Function Tests
• Multiple Organ Failure (diagnosis, mortality)
• Multiple Trauma (diagnosis, mortality)