Abstract | OBJECTIVE: ANIMALS: Twenty male and 15 female Holstein calves (100 to 180 kg), naturally infected with Giardia sp. PROCEDURE: In vitro fenbendazole susceptibility and resistance development was determined for a ruminant Giardia isolate by use of an adherence assay. Calves were treated as follows: group 1, a single administration of 5 mg of fenbendazole/kg of body weight; group 2, a single administration of 10 mg of fenbendazole/kg; group 3, 5 mg of fenbendazole/kg, every 24 hours for 3 days; group 4, 10 mg of fenbendazole/kg, every 24 hours for 3 days; group 5, 20 mg of fenbendazole/kg, every 24 hours for 3 days; group 6, 0.833 mg of fenbendazole/kg, every 24 hours for 6 days; and group 7, saline solution. Fecal Giardia cysts were counted on days -3 through -1 and 1 through 7, 9, 11, 13, 21, and 28 by use of sucrose gradient concentration and staining with a fluorescent monoclonal antibody. RESULTS: The 50% adherence inhibition concentration was 0.024 +/- 0.002 microgram/ml, and resistance could not be detected after 5 weeks of continuous culture at sublethal concentration of fenbendazole (0.01 microgram/kg). Fenbendazole was 100% effective in eliminating cysts from the feces within 6 days for calves in treatment groups 2-6. Reinfection was observed in some calves within the 28-day study period. CONCLUSIONS: CLINICAL RELEVANCE:
Fenbendazole is an effective and economical treatment for Giardia-associated diarrhea and growth rate reduction in calves.
|
Authors | R M O'Handley, M E Olson, T A McAllister, D W Morck, M Jelinski, G Royan, K J Cheng |
Journal | American journal of veterinary research
(Am J Vet Res)
Vol. 58
Issue 4
Pg. 384-8
(Apr 1997)
ISSN: 0002-9645 [Print] United States |
PMID | 9099384
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antiprotozoal Agents
- Fenbendazole
|
Topics |
- Animals
- Antiprotozoal Agents
(pharmacology, standards, therapeutic use)
- Cattle
- Cattle Diseases
(drug therapy, physiopathology, prevention & control)
- Dose-Response Relationship, Drug
- Feces
(parasitology)
- Female
- Fenbendazole
(pharmacology, standards, therapeutic use)
- Giardia
(drug effects, isolation & purification)
- Giardiasis
(drug therapy, prevention & control, veterinary)
- Male
|