Treatment of female hyperandrogenism: estroprogestinic therapy at low dose in an inversal sequential scheme.

Abstract

OBJECTIVE:

to investigate the effects of treatment with low dose of cyproterone acetate and ethynyl-estradiol on chemical and hormonal parameters in female hyperandrogenism.

DESIGN:

twenty patients, affected by clinical manifestations of hyperandrogenism, were studied basally and during treatment with 10 mg of cyproterone acetate associated with ethynyl-estradiol (20 m g) in an inversal sequential scheme for six months. Safety parameters were assessed throughout the study. Hirsutism was graded by Ferriman and Gallway score, and hormonal parameters were evaluated basally and after six months of therapy.

RESULTS:

after six months of therapy all patients showed a significant decrease of clinical and biochemical signs of hyperandrogenism, and normalization of ovarian parameters in seventeen women affected by PCOS.

CONCLUSIONS:

this treatment is an effective and well tolerated therapy. It is reasonable to consider this treatment as a safe procedure especially in view of a long-term administration.

• Authors: F P Ragonesi, F Lo Mastro, V Arena, M Ermini
• Journal: Acta Europaea fertilitatis (Acta Eur Fertil) 1995 Jul-Aug Vol. 26 Issue 4 Pg. 141-3 ISSN: 0587-2421 [Print] Italy
• PMID: 9098476 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Androgen Antagonists
• Estradiol Congeners
• Ethinyl Estradiol
• Cyproterone Acetate

Topics

• Adolescent
• Adult
• Androgen Antagonists (therapeutic use)
• Cyproterone Acetate (therapeutic use)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Estradiol Congeners (therapeutic use)
• Ethinyl Estradiol (therapeutic use)
• Female
• Humans
• Hyperandrogenism (drug therapy)