Abstract |
The effect of recombinant interferon-gamma (rIFN-gamma) on Leishmania infantum infection was investigated in vivo. BALB/c mice were injected intravenously (i.v.) with 10(7) promastigotes of Leishmania infantum. rIFN-gamma, 10(6) U given intraperitoneally (i.p.) daily on 3 consecutive days or 4 times on alternate days from day 7 (d7) post infection, had no detectable effect on the parasite burdens in liver, spleen, and lungs as compared to untreated mice. However rIFN-gamma enhanced the activity of Glucantime (50 mg/kg/d intraperitoneally for 7 days) in the liver and in the lungs. The additive effect of rIFN-gamma was still observed at day 30 post- infection, i.e. 15 days after cessation of therapy. By contrast the combination of the two drugs had no activity against splenic parasites.
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Authors | Y J Garin, A Sulahian, J P Gangneux, F Derouin |
Journal | Pathologie-biologie
(Pathol Biol (Paris))
Vol. 45
Issue 1
Pg. 48-51
(Jan 1997)
ISSN: 0369-8114 [Print] France |
PMID | 9097846
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiprotozoal Agents
- Organometallic Compounds
- Recombinant Proteins
- Meglumine
- Meglumine Antimoniate
- Interferon-gamma
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Topics |
- Animals
- Antiprotozoal Agents
(administration & dosage, pharmacology)
- Disease Models, Animal
- Drug Administration Schedule
- Female
- Interferon-gamma
(administration & dosage, pharmacology)
- Leishmania infantum
(drug effects)
- Leishmaniasis, Visceral
- Liver
(microbiology)
- Lung
(microbiology)
- Meglumine
(pharmacology)
- Meglumine Antimoniate
- Mice
- Mice, Inbred BALB C
- Organometallic Compounds
(pharmacology)
- Recombinant Proteins
- Spleen
(microbiology)
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