Activity of IFN-gamma in experimental Leishmania infantum murine visceral leishmaniasis.

Abstract

The effect of recombinant interferon-gamma (rIFN-gamma) on Leishmania infantum infection was investigated in vivo. BALB/c mice were injected intravenously (i.v.) with 10(7) promastigotes of Leishmania infantum. rIFN-gamma, 10(6) U given intraperitoneally (i.p.) daily on 3 consecutive days or 4 times on alternate days from day 7 (d7) post infection, had no detectable effect on the parasite burdens in liver, spleen, and lungs as compared to untreated mice. However rIFN-gamma enhanced the activity of Glucantime (50 mg/kg/d intraperitoneally for 7 days) in the liver and in the lungs. The additive effect of rIFN-gamma was still observed at day 30 post-infection, i.e. 15 days after cessation of therapy. By contrast the combination of the two drugs had no activity against splenic parasites.

• Authors: Y J Garin, A Sulahian, J P Gangneux, F Derouin
• Journal: Pathologie-biologie (Pathol Biol (Paris)) Vol. 45 Issue 1 Pg. 48-51 (Jan 1997) ISSN: 0369-8114 [Print] France
• PMID: 9097846 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiprotozoal Agents
• Organometallic Compounds
• Recombinant Proteins
• Meglumine
• Meglumine Antimoniate
• Interferon-gamma

Topics

• Animals
• Antiprotozoal Agents (administration & dosage, pharmacology)
• Disease Models, Animal
• Drug Administration Schedule
• Female
• Interferon-gamma (administration & dosage, pharmacology)
• Leishmania infantum (drug effects)
• Leishmaniasis, Visceral
• Liver (microbiology)
• Lung (microbiology)
• Meglumine (pharmacology)
• Meglumine Antimoniate
• Mice
• Mice, Inbred BALB C
• Organometallic Compounds (pharmacology)
• Recombinant Proteins
• Spleen (microbiology)