Interleukin-12 promotes recovery from viral encephalitis.

Abstract

Infusion of interleukin-12 (IL-12) enhances recovery from lethal experimental vesicular stomatitis virus (VSV) infection of the central nervous system (CNS). Interleukin-12 treatment resulted in: 1) increased survival frequency; 2) faster recovery from weight loss; 3) substantially decreased VSV titers in brain homogenates and diminished immunohistochemical detection of VSV antigens in tissue sections; 4) earlier and increased CNS expression of types 1, 2, and 3 nitric oxide synthase (NOS) and both major histocompatibility complex (MHC) class I and class II antigens; 5) earlier and increased blood and CNS levels of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). These results suggest that IL-12 enhances recovery from VSV infection of the CNS.

• Authors: T Komatsu, M Barna, C S Reiss
• Journal: Viral immunology (Viral Immunol) Vol. 10 Issue 1 Pg. 35-47 ( 1997) ISSN: 0882-8245 [Print] United States
• PMID: 9095530 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Histocompatibility Antigens Class I
• Histocompatibility Antigens Class II
• Tumor Necrosis Factor-alpha
• Interleukin-12
• Interferon-gamma
• Nitric Oxide Synthase

Topics

• Animals
• Brain (immunology, virology)
• CHO Cells
• Cricetinae
• Disease Models, Animal
• Encephalitis, Viral (drug therapy, immunology, mortality)
• Histocompatibility Antigens Class I (immunology)
• Histocompatibility Antigens Class II (immunology)
• Interferon-gamma (immunology)
• Interleukin-12 (administration & dosage)
• Male
• Mice
• Mice, Inbred BALB C
• Morbidity
• Nitric Oxide Synthase (biosynthesis)
• Rabbits
• Rhabdoviridae Infections (drug therapy, immunology, mortality)
• Time Factors
• Tumor Necrosis Factor-alpha (immunology)
• Vesicular stomatitis Indiana virus (immunology)
• Weight Loss