Abstract | BACKGROUND: In patients with Sezary syndrome undergoing extracorporeal photochemotherapy it is currently thought that photodamage of a congruent number of pathogenic circulating T cells is a necessary condition for a specific anticlonal response to be induced against these cells by the immune system. However other mechanisms of action, such as the induction of release by photoirradiated monocytes of some cytokines, are thought to cooperate in the induction of a therapeutic response. OBJECTIVE: METHOD: RESULTS: The results showed a significant increase of CD8+ and CD36+ and a significant decrease of CD25+ in all the treated patients. CONCLUSION:
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Authors | M Fimiani, P Rubegni, N Pimpinelli, M Mori, G De Aloe, L Andreassi |
Journal | Dermatology (Basel, Switzerland)
(Dermatology)
Vol. 194
Issue 2
Pg. 107-10
( 1997)
ISSN: 1018-8665 [Print] Switzerland |
PMID | 9094456
(Publication Type: Journal Article)
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Chemical References |
- CD36 Antigens
- Cytokines
- Receptors, Interleukin-2
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Topics |
- Aged
- CD36 Antigens
(analysis)
- CD8-Positive T-Lymphocytes
(drug effects, pathology)
- Cytokines
(metabolism)
- Female
- Follow-Up Studies
- Humans
- Immunohistochemistry
- Leukocyte Count
(drug effects)
- Leukocytes, Mononuclear
(drug effects, pathology)
- Lymphocyte Count
(drug effects)
- Lymphoma, T-Cell, Cutaneous
(drug therapy, pathology)
- Male
- Middle Aged
- Monocytes
(drug effects, pathology)
- Mycosis Fungoides
(drug therapy, pathology)
- Photopheresis
- Receptors, Interleukin-2
(analysis)
- Sezary Syndrome
(drug therapy, pathology)
- Skin Neoplasms
(drug therapy, pathology)
- T-Lymphocytes
(drug effects)
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