Abstract | BACKGROUND: OBJECTIVE: METHODS: The study contained two phases. In phase I, we analyzed the correlation between the intensity of itching and serum levels of intact PTH. In phase II, patients with moderate to severe pruritus were placed into two groups: one with high PTH levels and one with low levels. A double-blind, placebo-controlled study of capsaicin 0.025% cream was conducted in phase II. RESULTS: Serum levels of intact PTH did not correlate with the intensity of pruritus and did not significantly change during treatment with capsaicin or placebo. Capsaicin was significantly more effective in alleviating uremic pruritus than the placebo, and no serious side effects were noted. CONCLUSION:
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Authors | Y L Cho, H N Liu, T P Huang, D C Tarng |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 36
Issue 4
Pg. 538-43
(Apr 1997)
ISSN: 0190-9622 [Print] United States |
PMID | 9092738
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Parathyroid Hormone
- Phosphates
- Substance P
- Capsaicin
- Calcium
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Topics |
- Calcium
(blood)
- Capsaicin
(therapeutic use)
- Cross-Over Studies
- Double-Blind Method
- Female
- Humans
- Male
- Middle Aged
- Parathyroid Hormone
(blood)
- Phosphates
(blood)
- Pruritus
(blood, drug therapy)
- Renal Dialysis
(adverse effects)
- Substance P
(blood)
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