HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Immunotherapy of metastatic cancer in guinea pigs: failure of intralesional BCG to influence the results of radical surgery.

Abstract
Guinea pigs with growing intradermal transplants of a syngeneic hepatoma treated by intralesional injection of living BCG at a time when lymph node metastases were detectable by palpation were not cured but survived longer than did the controls. Treatment of the animals by excision of the transplant and draining lymph nodes, instead of by BCG, resulted in a significant number of cures. The cure rate of animals receiving both treatments was not demonstrably greater than that obtained in animals receiving surgery alone.
AuthorsJ T Hunter, T Okuda, H J Rapp
JournalJournal of the National Cancer Institute (J Natl Cancer Inst) Vol. 59 Issue 5 Pg. 1435-9 (Nov 1977) ISSN: 0027-8874 [Print] United States
PMID909107 (Publication Type: Journal Article)
Chemical References
  • BCG Vaccine
Topics
  • Animals
  • BCG Vaccine (therapeutic use)
  • Graft Rejection
  • Guinea Pigs
  • Lymph Node Excision
  • Lymphatic Metastasis (therapy)
  • Male
  • Neoplasm Transplantation
  • Neoplasms, Experimental (therapy)
  • Skin Neoplasms (immunology, therapy)
  • Transplantation, Isogeneic

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: