Protection from amphotericin B-induced lipid peroxidation in rats by fructose-1,6-diphosphate.

Abstract

Amphotericin B's (Amp B) usefulness is associated with a number of toxic cellular side effects. We investigated the in vivo effects of Amp B on the lipid peroxide (malondialdehyde [MDA]) levels in various organs of rats infused with 1.5 mg/kg body weight of Amp B. The rats (n = 8) experienced cardiac arrest following Amp B infusion. Among the organs, the kidney exhibited higher levels of MDA and was followed by brain > liver > lung > heart. Pretreatment of rats with 0.35 g/kg body weight of fructose-1,6-diphosphate (FDP) prior to Amp B infusion reduced the extent of MDA formation in all organs. These studies suggest that Amp B-associated toxicity in rats may involve the formation of lipid peroxide damage and FDP, in part by reducing these effects, may afford partial protection.

• Authors: M R Rao, K D Olinde, A K Markov
• Journal: Research communications in molecular pathology and pharmacology (Res Commun Mol Pathol Pharmacol) Vol. 95 Issue 2 Pg. 217-20 (Feb 1997) ISSN: 1078-0297 [Print] United States
• PMID: 9090757 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Fructosediphosphates
• Immunologic Factors
• Malondialdehyde
• Amphotericin B
• fructose-1,6-diphosphate

Topics

• Amphotericin B (administration & dosage, toxicity)
• Animals
• Anti-Bacterial Agents (administration & dosage, toxicity)
• Brain (drug effects, metabolism)
• Disease Models, Animal
• Fructosediphosphates (administration & dosage, pharmacology, therapeutic use)
• Heart (drug effects)
• Heart Arrest (chemically induced, drug therapy)
• Immunologic Factors (administration & dosage, pharmacology)
• Kidney (drug effects, metabolism)
• Lipid Peroxidation (drug effects)
• Liver (drug effects, metabolism)
• Lung (drug effects, metabolism)
• Male
• Malondialdehyde (metabolism)
• Myocardium (metabolism)
• Rats
• Rats, Sprague-Dawley